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  • How to manage genome-wide high-throughput data

    Posted on April 17th, 2009 Jessica P. No comments

    Today, we would like to propose you an important tool to manage genome-wide high-throughput data, available in the website of the University of California Santa Cruz. The UCSC Cancer Genomic Browser allows scientists to integrate and interactively display analysis of cancer genomic and clinical data. Genome heatmaps display copy number abnormality in samples of interest and chromosome or gene set visualizations are available. For each data sets, clinical data ( for instance for breast cancer: ER expression, PR, Her2, TP53 level, age, tissue source) are reported again in heatmaps.

    scanThus, in one page it’s possible to compare different studies or different kind of cancers and save the result of your analysis. Literature references are linked and standard statistical tools provide quantitative analysis of subsets of genome data. Then, in Genome Browser you can find out biological, genetic and biochemical information about the chromosomal portion or gene datasets of your choice.
    Indeed, with this tool user-defined gene sets can be filter and this is really useful to facilitate the analysis. In conclusion, the main goal of UCSC is to provide a platform to present data in an integrated system not only for cancer researchers but also for broader scientific community.

    Reference: Nature Methods April 2009, Vol.6, N. 4 ( http://genome-cancer.ucsc.edu )

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